Reaction Details Report a problem with these data
Target
Carbonic anhydrase 5A, mitochondrial
Ligand
BDBM25904
Substrate
n/a
Meas. Tech.
ChEMBL_565858 (CHEMBL959281)
Ki
1100±n/a nM
Citation
 Crocetti, L; Maresca, A; Temperini, C; Hall, RA; Scozzafava, A; Mühlschlegel, FA; Supuran, CT A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases. Bioorg Med Chem Lett 19:1371-5 (2009) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 5A, mitochondrial
Synonyms:
CA-VA | CA5 | CA5A | CAH5A_HUMAN | Carbonate dehydratase VA | Carbonic Anhydrase VA | Carbonic anhydrase 5A (CA VA) | Carbonic anhydrase 5A, mitochondrial | Carbonic anhydrase 5A, mitochondrial precursor | Carbonic anhydrase V | Carbonic anhydrase VA (CA VA)
Type:
Enzyme
Mol. Mass.:
34755.54
Organism:
Homo sapiens (Human)
Description:
Human (cloned) isozyme
Residue:
305
Sequence:
MLGRNTWKTSAFSFLVEQMWAPLWSRSMRPGRWCSQRSCAWQTSNNTLHPLWTVPVSVPGGTRQSPINIQWRDSVYDPQLKPLRVSYEAASCLYIWNTGYLFQVEFDDATEASGISGGPLENHYRLKQFHFHWGAVNEGGSEHTVDGHAYPAELHLVHWNSVKYQNYKEAVVGENGLAVIGVFLKLGAHHQTLQRLVDILPEIKHKDARAAMRPFDPSTLLPTCWDYWTYAGSLTTPPLTESVTWIIQKEPVEVAPSQLSAFRTLLFSALGEEEKMMVNNYRPLQPLMNRKVWASFQATNEGTRS
  
Inhibitor
Name:
BDBM25904
Synonyms:
2-(hydrazinecarbonyl)-3-phenyl-1H-indole-5-sulfonamide | BMC173212 Compound 1 | CHEMBL262628 | indole sulfonamide, L
Type:
Small organic molecule
Emp. Form.:
C15H14N4O3S
Mol. Mass.:
330.362
SMILES:
NNC(=O)c1[nH]c2ccc(cc2c1-c1ccccc1)S(N)(=O)=O
Structure:
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