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Target
Sodium/glucose cotransporter 2
Ligand
BDBM20880
Substrate
n/a
Meas. Tech.
ChEMBL_566719 (CHEMBL961711)
EC50
3±n/a nM
Citation
 Washburn, WN Development of the renal glucose reabsorption inhibitors: a new mechanism for the pharmacotherapy of diabetes mellitus type 2. J Med Chem 52:1785-94 (2009) [PubMed]  Article 
Target
Name:
Sodium/glucose cotransporter 2
Synonyms:
SC5A2_RAT | Sglt2 | Slc5a2
Type:
PROTEIN
Mol. Mass.:
72969.23
Organism:
Rattus norvegicus
Description:
ChEMBL_938467
Residue:
670
Sequence:
MEGHVEEGSELGEQKVLIDNPADILVIAAYFLLVIGVGLWSMFRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFVPVYLTAGVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILAGAFILTGYAFHEVGGYSGLFDKYLGAVTSLTVSKDPAVGNISSTCYQPRPDSYHLLRDPVTGGLPWPALLLGLTIVSGWHWCSDQVIVQRCLAGKNLTHIKAGCILCGYLKLMPMFLMVMPGMISRILYPDEVACVVPEVCKRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFVPRVNEKGAFWGLIGGLLMGLARLIPEFFFGTGSCVRPSACPAIFCRVHYLYFAIILFFCSGFLTLAISRCTAPIPQKHLHRLVFSLRHSKEEREDLDAEELEGPAPPPVQNGCQECAMGIEEVQSPAPGLLRQCLLWFCGMSKSGSGSPPPTTEEVAATTRRLEDISEDPSWARVVNLNALLMMTVAVFLWGFYA
  
Inhibitor
Name:
BDBM20880
Synonyms:
(2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl}-6-(hydroxymethyl)oxane-3,4,5-triol | BMS-512148 | C-aryl glucoside, 6 | CHEMBL429910 | Dapagliflozin
Type:
Small organic molecule
Emp. Form.:
C21H25ClO6
Mol. Mass.:
408.873
SMILES:
CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Structure:
Search PDB for entries with ligand similarity: