Reaction Details
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Transient receptor potential cation channel subfamily V member 4
Ligand
BDBM50240777
Substrate
n/a
Meas. Tech.
ChEMBL_501553 (CHEMBL986820)
EC50
370±n/a nM
Citation
Klausen, TK; Pagani, A; Minassi, A; Ech-Chahad, A; Prenen, J; Owsianik, G; Hoffmann, EK; Pedersen, SF; Appendino, G; Nilius, B Modulation of the transient receptor potential vanilloid channel TRPV4 by 4alpha-phorbol esters: a structure-activity study. J Med Chem 52:2933-9 (2009) [PubMed] Article More Info.:
Target
Name:
Transient receptor potential cation channel subfamily V member 4
Synonyms:
TRPV4_MOUSE | Trp12 | Trpv4 | Vrl2 | Vroac
Type:
PROTEIN
Mol. Mass.:
98032.61
Organism:
Mus musculus
Description:
ChEMBL_1514430
Residue:
871
Sequence:
MADPGDGPRAAPGEVAEPPGDESGTSGGEAFPLSSLANLFEGEEGSSSLSPVDASRPAGPGDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHPSDNKRWRRKVVEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLSFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTSLHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCSRLFPDSNLETVLNNDGLSPLMMAAKTGKIGVFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYDLSSLDTCGEEVSVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLFFFTSIKDLFTKKCPGVNSLFVDGSFQLLYFIYSVLVVVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVTLLNPCTNMKVCDEDQSNCTVPTYPACRDSETFSAFLLDLFKLTIGMGDLEMLSSAKYPVVFILLLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPGKSEIYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSSADEVVVPLDNLGNPNCDGHQQGYAPKWRTDDAPL
Inhibitor
Name:
BDBM50240777
Synonyms:
4alpha-phorbol-didecanoate | CHEMBL118987 | Decanoic acid (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9-decanoyloxy-4a,7b-dihydroxy-3-hydroxymethyl-1,1,6,8-tetramethyl-5-oxo-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-cyclopropa[3,4]benzo[1,2-e]azulen-9a-yl ester
Type:
Small organic molecule
Emp. Form.:
C40H64O8
Mol. Mass.:
672.9314
SMILES:
CCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(=O)CCCCCCCCC |r,c:29,t:18|
Structure:
