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Target
Glutathione reductase, mitochondrial
Ligand
BDBM50293666
Substrate
n/a
Meas. Tech.
ChEMBL_571638 (CHEMBL1031293)
Ki
17900±n/a nM
Citation
 Sentürk, M; Talaz, O; Ekinci, D; Cavdar, H; Küfrevioglu, OI In vitro inhibition of human erythrocyte glutathione reductase by some new organic nitrates. Bioorg Med Chem Lett 19:3661-3 (2009) [PubMed]  Article 
Target
Name:
Glutathione reductase, mitochondrial
Synonyms:
GLUR | GRD1 | GSHR_HUMAN | GSR | Glutathione reductase | Glutathione reductase (GR)
Type:
Enzyme
Mol. Mass.:
56271.52
Organism:
Homo sapiens (Human)
Description:
P00390
Residue:
522
Sequence:
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
  
Inhibitor
Name:
BDBM50293666
Synonyms:
(1S(R),3S(R),4S(R),6S(R))-4,6-Dihydroxycyclo-hexane-1,3-diyl dinitrate | CHEMBL561220
Type:
Small organic molecule
Emp. Form.:
C6H10N2O8
Mol. Mass.:
238.1522
SMILES:
OC1CC(O)C(CC1O[N+]([O-])=O)O[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: