Reaction Details Report a problem with these data
Target
Elongation of very long chain fatty acids protein 6
Ligand
BDBM50293790
Substrate
n/a
Meas. Tech.
ChEMBL_572238 (CHEMBL1031016)
IC50
32±n/a nM
Citation
 Nagase, T; Takahashi, T; Sasaki, T; Nagumo, A; Shimamura, K; Miyamoto, Y; Kitazawa, H; Kanesaka, M; Yoshimoto, R; Aragane, K; Tokita, S; Sato, N Synthesis and biological evaluation of a novel 3-sulfonyl-8-azabicyclo[3.2.1]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors. J Med Chem 52:4111-4 (2009) [PubMed]  Article 
Target
Name:
Elongation of very long chain fatty acids protein 6
Synonyms:
ELOV6_HUMAN | ELOVL6 | FACE | LCE
Type:
PROTEIN
Mol. Mass.:
31392.28
Organism:
Homo sapiens (Human)
Description:
ChEMBL_572238
Residue:
265
Sequence:
MNMSVLTLQEYEFEKQFNENEAIQWMQENWKKSFLFSALYAAFIFGGRHLMNKRAKFELRKPLVLWSLTLAVFSIFGALRTGAYMVYILMTKGLKQSVCDQGFYNGPVSKFWAYAFVLSKAPELGDTIFIILRKQKLIFLHWYHHITVLLYSWYSYKDMVAGGGWFMTMNYGVHAVMYSYYALRAAGFRVSRKFAMFITLSQITQMLMGCVVNYLVFCWMQHDQCHSHFQNIFWSSLMYLSYLVLFCHFFFEAYIGKMRKTTKAE
  
Inhibitor
Name:
BDBM50293790
Synonyms:
CHEMBL550828 | N-(4-Isopropylphenyl)-3-endo-(phenylsulfonyl)-8-azabicyclo[3.2.1]octane-8-carboxamide
Type:
Small organic molecule
Emp. Form.:
C23H28N2O3S
Mol. Mass.:
412.545
SMILES:
CC(C)c1ccc(NC(=O)N2[C@@H]3CC[C@@H]2CC(C3)S(=O)(=O)c2ccccc2)cc1 |r,THB:18:16:10:12.13|
Structure:
Search PDB for entries with ligand similarity: