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Target
Elongation of very long chain fatty acids protein 6
Ligand
BDBM50293789
Substrate
n/a
Meas. Tech.
ChEMBL_572244 (CHEMBL1031022)
IC50
94±n/a nM
Citation
 Nagase, T; Takahashi, T; Sasaki, T; Nagumo, A; Shimamura, K; Miyamoto, Y; Kitazawa, H; Kanesaka, M; Yoshimoto, R; Aragane, K; Tokita, S; Sato, N Synthesis and biological evaluation of a novel 3-sulfonyl-8-azabicyclo[3.2.1]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors. J Med Chem 52:4111-4 (2009) [PubMed]  Article 
Target
Name:
Elongation of very long chain fatty acids protein 6
Synonyms:
ELOV6_MOUSE | Elovl6 | Face | Lce | Masr
Type:
PROTEIN
Mol. Mass.:
31624.93
Organism:
Mus musculus
Description:
ChEMBL_572244
Residue:
267
Sequence:
MNMSVLTLQEYEFEKQFNENEAIQWMQENWKKSFLFSALYAAFIFGGRHLMNKRAKFELRKPLVLWSLTLAVFSIFGALRTGAYMLYILMTKGLKQSVCDQSFYNGPVSKFWAYAFVLSKAPELGDTIFIILRKQKLIFLHWYHHITVLLYSWYSYKDMVAGGGWFMTMNYGVHAVMYSYYALRAAGFRVSRKFAMFITLSQITQMLMGCVINYLVFNWMQHDNDQCYSHFQNIFWSSLMYLSYLVLFCHFFFEAYIGKVKKATKAE
  
Inhibitor
Name:
BDBM50293789
Synonyms:
3-endo-(Pyridin-2-ylsulfonyl)-N-[4-(trifluoromethyl)phenyl]-8-azabicyclo[3.2.1]octane-8-carboxamide | CHEMBL549545
Type:
Small organic molecule
Emp. Form.:
C20H20F3N3O3S
Mol. Mass.:
439.451
SMILES:
FC(F)(F)c1ccc(NC(=O)N2[C@@H]3CC[C@@H]2CC(C3)S(=O)(=O)c2ccccn2)cc1 |r,THB:19:17:11:13.14|
Structure:
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