Reaction Details Report a problem with these data
Target
Glyoxalase I
Ligand
BDBM50294134
Substrate
n/a
Meas. Tech.
ChEMBL_571116 (CHEMBL1030416)
Ki
6.17±n/a nM
Citation
 More, SS; Vince, R Inhibition of glyoxalase I: the first low-nanomolar tight-binding inhibitors. J Med Chem 52:4650-6 (2009) [PubMed]  Article 
Target
Name:
Glyoxalase I
Synonyms:
GLO1 | LGUL_YEAST | Lactoylglutathione lyase
Type:
PROTEIN
Mol. Mass.:
37210.98
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_571116
Residue:
326
Sequence:
MSTDSTRYPIQIEKASNDPTLLLNHTCLRVKDPARTVKFYTEHFGMKLLSRKDFEEAKFSLYFLSFPKDDIPKNKNGEPDVFSAHGVLELTHNWGTEKNPDYKINNGNEEPHRGFGHICFSVSDINKTCEELESQGVKFKKRLSEGRQKDIAFALGPDGYWIELITYSREGQEYPKGSVGNKFNHTMIRIKNPTRSLEFYQNVLGMKLLRTSEHESAKFTLYFLGYGVPKTDSVFSCESVLELTHNWGTENDPNFHYHNGNSEPQGYGHICISCDDAGALCKEIEVKYGDKIQWSPKFNQGRMKNIAFLKDPDGYSIEVVPHGLIA
  
Inhibitor
Name:
BDBM50294134
Synonyms:
(S)-2-Amino-4-{(S)-3-[(4-bromo-phenyl)-hydroxy-carbamoyl]-1-carboxyaminocarbonyl-propylcarbamoyl}-butyric acid TFA | CHEMBL549339
Type:
Small organic molecule
Emp. Form.:
C18H23BrN4O8
Mol. Mass.:
503.301
SMILES:
N[C@@H](CCC(=O)N[C@@H](CCC(=O)N(O)c1ccc(Br)cc1)C(=O)NCC(O)=O)C(O)=O |r|
Structure:
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