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Target
Growth factor receptor-bound protein 2
Ligand
BDBM50294419
Substrate
n/a
Meas. Tech.
ChEMBL_575368 (CHEMBL1027042)
Kd
3600±n/a nM
Citation
 Jiang, S; Liao, C; Bindu, L; Yin, B; Worthy, KW; Fisher, RJ; Burke, TR; Nicklaus, MC; Roller, PP Discovery of thioether-bridged cyclic pentapeptides binding to Grb2-SH2 domain with high affinity. Bioorg Med Chem Lett 19:2693-8 (2009) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50294419
Synonyms:
3-[(5S,8S,11S,14S,17R)-17-carbamoyl-11-(carbamoylmethyl)-3,6,9,12,15-pentaoxo-5-{[4-(phosphonooxy)phenyl]methyl}-14-(propan-2-yl)-1-thia-4,7,10,13,16-pentaazacyclooctadecan-8-yl]propanoic acid | CHEMBL539206
Type:
Small organic molecule
Emp. Form.:
C28H40N7O13PS
Mol. Mass.:
745.695
SMILES:
CC(C)[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc2ccc(OP(O)(O)=O)cc2)NC(=O)CSC[C@H](NC1=O)C(N)=O |r|
Structure:
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