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Target
Sodium/hydrogen exchanger 1
Ligand
BDBM50297575
Substrate
n/a
Meas. Tech.
ChEMBL_583577 (CHEMBL1059092)
IC50
10.8±n/a nM
Citation
 Zhang, R; Dong, J; Xu, YG; Hua, WY; Wen, N; You, QD Synthesis and bioactivity of substituted indan-1-ylideneaminoguanidine derivatives. Eur J Med Chem 44:3771-6 (2009) [PubMed]  Article 
Target
Name:
Sodium/hydrogen exchanger 1
Synonyms:
NHE-1 | Na(+)/H(+) exchanger 1 | Nhe1 | SL9A1_RAT | Slc9a1 | Solute carrier family 9 member 1
Type:
PROTEIN
Mol. Mass.:
91655.00
Organism:
Rattus norvegicus
Description:
ChEMBL_862370
Residue:
820
Sequence:
MMLRWSGIWGLYPPRIFPSLLVVVALVGLLPVLRSHGLQLNPTASTIRGSEPPRERSIGDVTTAPSEPLHHPDDRNLTNLYIEHGAKPVRKAFPVLDIDYLHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLLYAVCLVGGEQINNIGLLDTLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFASYEYVGISDIFLGFLSFFVVSLGGVFVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHQWNWTFVISTLLFCLIARVLGVLVLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSAASERILPALSKDKEEEIRKILRSNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKITNYLTVPAHKLDSPTMSRARIGSDPLAYEPKADLPVITIDPASPQSPESVDLVNEELKGKVLGLKRGPRTTPEEEEEDEDGVIMIRSKEPSSPGTDDVFTPGPSDSPGSQRIQRCLSDPGPHPEPGEGEPFIPKGQ
  
Inhibitor
Name:
BDBM50297575
Synonyms:
2-{[(1E)-2-(1H-1,3-benzodiazol-2-ylsulfanyl)-4,5,6-trimethoxy-2,3-dihydro-1H-inden-1-ylidene]amino}guanidine hydrochloride | CHEMBL557532
Type:
Small organic molecule
Emp. Form.:
C20H22N6O3S
Mol. Mass.:
426.492
SMILES:
COc1cc2C(=NN=C(N)N)C(Cc2c(OC)c1OC)Sc1nc2ccccc2[nH]1 |w:6.6,(.51,-14.95,;.5,-13.41,;-.83,-12.64,;-.84,-11.11,;-2.16,-10.35,;-2.48,-8.84,;-1.45,-7.7,;.06,-8.01,;1.08,-6.86,;2.59,-7.18,;.6,-5.4,;-4.01,-8.69,;-4.64,-10.09,;-3.49,-11.11,;-3.49,-12.64,;-4.83,-13.41,;-6.16,-12.64,;-2.16,-13.41,;-2.16,-14.95,;-3.5,-15.73,;-4.78,-7.36,;-6.32,-7.36,;-7.23,-6.1,;-8.71,-6.58,;-10.05,-5.82,;-11.38,-6.59,;-11.38,-8.14,;-10.05,-8.91,;-8.71,-8.14,;-7.23,-8.61,)|
Structure:
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