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Target
Sodium/hydrogen exchanger 1
Ligand
BDBM50297583
Substrate
n/a
Meas. Tech.
ChEMBL_583577 (CHEMBL1059092)
IC50
1.17±n/a nM
Citation
 Zhang, R; Dong, J; Xu, YG; Hua, WY; Wen, N; You, QD Synthesis and bioactivity of substituted indan-1-ylideneaminoguanidine derivatives. Eur J Med Chem 44:3771-6 (2009) [PubMed]  Article 
Target
Name:
Sodium/hydrogen exchanger 1
Synonyms:
NHE-1 | Na(+)/H(+) exchanger 1 | Nhe1 | SL9A1_RAT | Slc9a1 | Solute carrier family 9 member 1
Type:
PROTEIN
Mol. Mass.:
91655.00
Organism:
Rattus norvegicus
Description:
ChEMBL_862370
Residue:
820
Sequence:
MMLRWSGIWGLYPPRIFPSLLVVVALVGLLPVLRSHGLQLNPTASTIRGSEPPRERSIGDVTTAPSEPLHHPDDRNLTNLYIEHGAKPVRKAFPVLDIDYLHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLLYAVCLVGGEQINNIGLLDTLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFASYEYVGISDIFLGFLSFFVVSLGGVFVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHQWNWTFVISTLLFCLIARVLGVLVLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSAASERILPALSKDKEEEIRKILRSNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKITNYLTVPAHKLDSPTMSRARIGSDPLAYEPKADLPVITIDPASPQSPESVDLVNEELKGKVLGLKRGPRTTPEEEEEDEDGVIMIRSKEPSSPGTDDVFTPGPSDSPGSQRIQRCLSDPGPHPEPGEGEPFIPKGQ
  
Inhibitor
Name:
BDBM50297583
Synonyms:
CHEMBL560806 | N''-[2-(1H-benzimidazol-2-ylthio)-5-nitro-2,3-dihydro-1H-inden-1-ylidene]carbonohydrazonic diamide
Type:
Small organic molecule
Emp. Form.:
C17H15N7O2S
Mol. Mass.:
381.412
SMILES:
NC(N)=NN=C1C(Cc2cc(ccc12)[N+]([O-])=O)Sc1nc2ccccc2[nH]1 |w:4.3,(23.89,-33.56,;22.38,-33.25,;21.9,-31.79,;21.36,-34.4,;19.85,-34.09,;18.83,-35.25,;17.29,-35.09,;16.68,-36.51,;17.83,-37.52,;17.84,-39.05,;19.17,-39.81,;20.5,-39.03,;20.48,-37.5,;19.16,-36.75,;19.19,-41.36,;17.86,-42.14,;20.53,-42.12,;16.51,-33.77,;14.97,-33.78,;14.05,-32.53,;12.59,-33.02,;11.25,-32.25,;9.92,-33.03,;9.92,-34.57,;11.25,-35.34,;12.6,-34.56,;14.07,-35.03,)|
Structure:
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