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Target
B-cell receptor CD22
Ligand
BDBM50274296
Substrate
n/a
Meas. Tech.
ChEMBL_599602 (CHEMBL1040214)
IC50
3840±n/a nM
Citation
 Abdu-Allah, HH; Watanabe, K; Hayashizaki, K; Takaku, C; Tamanaka, T; Takematsu, H; Kozutsumi, Y; Tsubata, T; Ishida, H; Kiso, M Potent small molecule mouse CD22-inhibitors: exploring the interaction of the residue at C-2 of sialic acid scaffold. Bioorg Med Chem Lett 19:5573-5 (2009) [PubMed]  Article 
Target
Name:
B-cell receptor CD22
Synonyms:
B-lymphocyte cell adhesion molecule | BL-CAM | CD22_MOUSE | CD_antigen=CD22 | Cd22 | Lyb-8 | Sialic acid-binding Ig-like lectin 2 | Siglec-2 | Siglec2 | T-cell surface antigen Leu-14
Type:
PROTEIN
Mol. Mass.:
96597.27
Organism:
Mus musculus
Description:
ChEMBL_727025
Residue:
862
Sequence:
MRVHYLWLLLILGHAASAQYSSANDWTVDHPQTLFAWEGACIRIPCKYKTPLPKARLDNILLFQNYEFDKATKKFKGTVLYNKAEPELYPPKQRRVTFLGNSIDNCTLKIHPIRANDSGNLGLRMTAGTERWMEPIHLNVSEKPFQPYIQMPSEIRESQSVTLTCGLNFSCFEYDILLQWFLEDSKITSVTPSVTSITSSVTSSIKNVYTESKLTFQPKWTDHGKSVKCQVQHSSEVLSERTVRLDVKYTPKLEIKVNPTEVEKNNSVTMTCRVNSSNPKLRTVAVSWFKDGRPLEDQELEQEQQMSKLILHSVTKDMRGKYRCQASNDIGPGESEEVELTVHYAPEPSRVHIYPSPAEEGQSVELICESLASPSATNYTWYHNRKPIPGDTQEKLRIPKVSPWHAGNYSCLAENRLGHGKIDQEAKLDVHYAPKAVTTVIQSFTPILEGDSVTLVCRYNSSNPDVTSYRWNPQGSGSVLKPGVLRIQKVTWDSMPVSCAACNHKCSWALPVILNVHYAPRDVKVLKVSPASEIRAGQRVLLQCDFAESNPAEVRFFWKKNGSLVQEGRYLSFGSVSPEDSGNYNCMVNNSIGETLSQAWNLQVLYAPRRLRVSISPGDHVMEGKKATLSCESDANPPISQYTWFDSSGQDLHSSGQKLRLEPLEVQHTGSYRCKGTNGIGTGESPPSTLTVYYSPETIGKRVALGLGFCLTICILAIWGMKIQKKWKQNRSQQGLQENSSGQSFFVRNKKARRTPLSEGPQSQGCYNPAMDDTVSYAILRFPESDMHNAGDAGTPATQAPPPNNSDSVTYSVIQKRPMGDYENVNPSCPEDESIHYSELVQFGAGKRPQAKEDVDYVTLKH
  
Inhibitor
Name:
BDBM50274296
Synonyms:
CHEMBL501599 | p-Methoxyphenyl (3,5,9-trideoxy-5-glycolamido-9-(4'-hydroxy-4-biphenyl)-acetamido-D-glycero-alpha-D-galacto-2-nonulopyranosylonicacid)-(2->6)-beta-D-galactopyranoside
Type:
Small organic molecule
Emp. Form.:
C38H46N2O17
Mol. Mass.:
802.775
SMILES:
COc1ccc(O[C@@H]2O[C@H](CO[C@@]3(C[C@H](O)[C@@H](NC(=O)CO)[C@@H](O3)[C@H](O)[C@H](O)CNC(=O)Cc3ccc(cc3)-c3ccc(O)cc3)C(O)=O)[C@H](O)[C@H](O)[C@H]2O)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: