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Target
D(4) dopamine receptor
Ligand
BDBM50180913
Substrate
n/a
Meas. Tech.
ChEMBL_603133 (CHEMBL1038855)
Ki
11.3±n/a nM
Citation
 Schulze, M; Müller, FK; Mason, JM; Görls, H; Lehmann, J; Enzensperger, C Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities? Bioorg Med Chem 17:6898-907 (2009) [PubMed]  Article 
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM50180913
Synonyms:
11-methyl-11-aza-tricyclo[12.4.0.0.3,8]octadeca-1(18),3(8),4,6,14,16-hexaen-6-ol | 11-methyl-11-aza-tricyclo[12.4.0.03,8]octadeca-1(14),3,5,7,15,17-hexaen-6-ol | 3-hydroxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine | 7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecin-3-ol | CHEMBL1204122 | CHEMBL201170 | LE404
Type:
Small organic molecule
Emp. Form.:
C18H21NO
Mol. Mass.:
267.3654
SMILES:
CN1CCc2ccccc2Cc2ccc(O)cc2CC1
Structure:
Search PDB for entries with ligand similarity: