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Target
Cyclin-dependent kinase 2
Ligand
BDBM50306875
Substrate
n/a
Meas. Tech.
ChEMBL_608662 (CHEMBL1067148)
IC50
>30000±n/a nM
Citation
 Hegde, VR; Borges, S; Pu, H; Patel, M; Gullo, VP; Wu, B; Kirschmeier, P; Williams, MJ; Madison, V; Fischmann, T; Chan, TM Semi-synthetic aristolactams--inhibitors of CDK2 enzyme. Bioorg Med Chem Lett 20:1384-7 (2010) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50306875
Synonyms:
8,9-Dihydroxy-6H-benzo[f][1,3]dioxolo[4',5':4,5]benzo[1,2,3-cd]indol-5-one | CHEMBL611081
Type:
Small organic molecule
Emp. Form.:
C16H9NO5
Mol. Mass.:
295.2464
SMILES:
Oc1ccc2c(cc3NC(=O)c4cc5OCOc5c2c34)c1O
Structure:
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