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Target
Dual specificity protein kinase CLK1
Ligand
BDBM50312990
Substrate
n/a
Meas. Tech.
ChEMBL_616128 (CHEMBL1102991)
Kd
16±n/a nM
Citation
 Gong, L; Hirschfeld, D; Tan, YC; Heather Hogg, J; Peltz, G; Avnur, Z; Dunten, P Discovery of potent and bioavailable GSK-3beta inhibitors. Bioorg Med Chem Lett 20:1693-6 (2010) [PubMed]  Article 
Target
Name:
Dual specificity protein kinase CLK1
Synonyms:
CDC-like kinase 1 | CDC-like kinase 1 (CLK1) | CDC2-like kinase 1 (CLK1) | CLK | CLK1 | CLK1_HUMAN | Dual specificity protein kinase CLK1 | Dual specificity protein kinase CLK1/CLK4 | Dual specificty protein kinase CLK1
Type:
Protein
Mol. Mass.:
57322.21
Organism:
Homo sapiens (Human)
Description:
P49759
Residue:
484
Sequence:
MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI
  
Inhibitor
Name:
BDBM50312990
Synonyms:
(R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-fluoro-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione | CHEMBL1082152
Type:
Small organic molecule
Emp. Form.:
C22H20FN3O4
Mol. Mass.:
409.4103
SMILES:
Cn1cc(C2=C(C(=O)NC2=O)c2cccc(NCC(O)CO)c2)c2cc(F)ccc12 |t:4|
Structure:
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