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Target
KiSS-1 receptor
Ligand
BDBM50322293
Substrate
n/a
Meas. Tech.
ChEMBL_642625 (CHEMBL1176768)
IC50
26±n/a nM
Citation
 Kobayashi, T; Sasaki, S; Tomita, N; Fukui, S; Nakayama, M; Kiba, A; Kusaka, M; Matsumoto, S; Yamaguchi, M; Itoh, F; Baba, A 2-acylamino-4,6-diphenylpyridine derivatives as novel GPR54 antagonists with good brain exposure and in vivo efficacy for plasma LH level in male rats. Bioorg Med Chem 18:5157-71 (2010) [PubMed]  Article 
Target
Name:
KiSS-1 receptor
Synonyms:
Gpr54 | KISSR_RAT | Kiss1r
Type:
PROTEIN
Mol. Mass.:
42915.37
Organism:
Rattus norvegicus
Description:
ChEMBL_1448383
Residue:
396
Sequence:
MAAEATLGPNVSWWAPSNASGCPGCGVNASDGPGSAPRPLDAWLVPLFFAALMLLGLVGNSLVIFVICRHKHMQTVTNFYIANLAATDVTFLLCCVPFTALLYPLPTWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALTVSLSIWVGSAAVSAPVLALHRLSPGPHTYCSEAFPSRALERAFALYNLLALYLLPLLATCACYGAMLRHLGRAAVRPAPTDGALQGQLLAQRAGAVRTKVSRLVAAVVLLFAACWGPIQLFLVLQALGPSGAWHPRSYAAYALKIWAHCMSYSNSALNPLLYAFLGSHFRQAFCRVCPCGPQRQRRPHASAHSDRAAPHSVPHSRAAHPVRVRTPEPGNPVRRSPSVQDEHTAPL
  
Inhibitor
Name:
BDBM50322293
Synonyms:
CHEMBL1170911 | N-[3-Cyano-6-(4-fluoro-2-hydroxyphenyl)-4-{3-[(N-methylglycyl)amino]phenyl}pyridin-2-yl]furan-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
C26H20FN5O4
Mol. Mass.:
485.4665
SMILES:
CNCC(=O)Nc1cccc(c1)-c1cc(nc(NC(=O)c2ccco2)c1C#N)-c1ccc(F)cc1O
Structure:
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