Reaction Details Report a problem with these data
Target
Cell division protein FtsZ
Ligand
BDBM50335239
Substrate
n/a
Meas. Tech.
ChEMBL_702652 (CHEMBL1657588)
IC50
7690±n/a nM
Citation
 Kumar, K; Awasthi, D; Lee, SY; Zanardi, I; Ruzsicska, B; Knudson, S; Tonge, PJ; Slayden, RA; Ojima, I Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents. J Med Chem 54:374-81 (2011) [PubMed]  Article 
Target
Name:
Cell division protein FtsZ
Synonyms:
FTSZ_MYCTU | ftsZ
Type:
PROTEIN
Mol. Mass.:
38736.30
Organism:
Mycobacterium tuberculosis
Description:
ChEMBL_1470459
Residue:
379
Sequence:
MTPPHNYLAVIKVVGIGGGGVNAVNRMIEQGLKGVEFIAINTDAQALLMSDADVKLDVGRDSTRGLGAGADPEVGRKAAEDAKDEIEELLRGADMVFVTAGEGGGTGTGGAPVVASIARKLGALTVGVVTRPFSFEGKRRSNQAENGIAALRESCDTLIVIPNDRLLQMGDAAVSLMDAFRSADEVLLNGVQGITDLITTPGLINVDFADVKGIMSGAGTALMGIGSARGEGRSLKAAEIAINSPLLEASMEGAQGVLMSIAGGSDLGLFEINEAASLVQDAAHPDANIIFGTVIDDSLGDEVRVTVIAAGFDVSGPGRKPVMGETGGAHRIESAKAGKLTSTLFEPVDAVSVPLHTNGATLSIGGDDDDVDVPPFMRR
  
Inhibitor
Name:
BDBM50335239
Synonyms:
CHEMBL1651202 | butyl 2-cyclohexyl-6-(diethylamino)-1H-benzo[d]imidazol-5-ylcarbamate
Type:
Small organic molecule
Emp. Form.:
C22H34N4O2
Mol. Mass.:
386.531
SMILES:
CCCCOC(=O)Nc1cc2nc([nH]c2cc1N(CC)CC)C1CCCCC1
Structure:
Search PDB for entries with ligand similarity: