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Target
Tyrosine-protein phosphatase non-receptor type 9
Ligand
BDBM50343148
Substrate
n/a
Meas. Tech.
ChEMBL_745338 (CHEMBL1775413)
IC50
>50000±n/a nM
Citation
 Chen, L; Zhou, B; Zhang, S; Wu, L; Wang, Y; Franzblau, SG; Zhang, ZY Identification and characterization of novel inhibitors of mPTPB, an essential virulent phosphatase from Mycobacterium tuberculosis. ACS Med Chem Lett 1:355-359 (2010) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 9
Synonyms:
3.1.3.48 | PTN9_HUMAN | PTP-MEG2 | PTPN9 | PTPase MEG2 | Protein-tyrosine phosphatase MEG2 | Protein-tyrosine phosphatase MEG2 (PTP-Meg2) | Tyrosine-protein phosphatase non-receptor type 9
Type:
n/a
Mol. Mass.:
68030.33
Organism:
Homo sapiens (Human)
Description:
P43378
Residue:
593
Sequence:
MEPATAPRPDMAPELTPEEEQATKQFLEEINKWTVQYNVSPLSWNVAVKFLMARKFDVLRAIELFHSYRETRRKEGIVKLKPHEEPLRSEILSGKFTILNVRDPTGASIALFTARLHHPHKSVQHVVLQALFYLLDRAVDSFETQRNGLVFIYDMCGSNYANFELDLGKKVLNLLKGAFPARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERIQILKTSEVTQHLPRECLPENLGGYVKIDLATWNFQFLPQVNGHPDPFDEIILFSLPPALDWDSVHVPGPHAMTIQELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ
  
Inhibitor
Name:
BDBM50343148
Synonyms:
CHEMBL1773181 | N1-(1-(4-(4-fluorophenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)-N2-(pyridin-3-ylmethyl)oxalamide
Type:
Small organic molecule
Emp. Form.:
C25H28FN5O2S
Mol. Mass.:
481.586
SMILES:
CC(NC(=O)C(=O)NCc1cccnc1)C(N1CCN(CC1)c1ccc(F)cc1)c1cccs1
Structure:
Search PDB for entries with ligand similarity: