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Target
Histamine H3 receptor
Ligand
BDBM50355128
Substrate
n/a
Meas. Tech.
ChEMBL_772497 (CHEMBL1839389)
Ki
12±n/a nM
Citation
 Tao, M; Raddatz, R; Aimone, LD; Hudkins, RL Synthesis and structure-activity relationships of 4,5-fused pyridazinones as histamine H3 receptor antagonists. Bioorg Med Chem Lett 21:6126-30 (2011) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50355128
Synonyms:
CHEMBL1835780
Type:
Small organic molecule
Emp. Form.:
C27H28ClN3O2S
Mol. Mass.:
494.048
SMILES:
C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1nn(Cc2ccc(Cl)cc2)c(=O)c2ccsc12 |r|
Structure:
Search PDB for entries with ligand similarity: