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Target
DNA polymerase iota
Ligand
BDBM50356642
Substrate
n/a
Meas. Tech.
ChEMBL_785411 (CHEMBL1919790)
IC50
7100±n/a nM
Citation
 Maruo, S; Kuriyama, I; Kuramochi, K; Tsubaki, K; Yoshida, H; Mizushina, Y Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response. Bioorg Med Chem 19:5803-12 (2011) [PubMed]  Article 
Target
Name:
DNA polymerase iota
Synonyms:
POLI_MOUSE | Poli | Rad30b
Type:
PROTEIN
Mol. Mass.:
79658.67
Organism:
Mus musculus
Description:
ChEMBL_811415
Residue:
717
Sequence:
MEPLHAGAAGSSRAVCSQGPPTQISSSRVIVHVDLDCFYAQVEMISNPELKDRPLGVQQKYLVVTCNYEARKLGVRKLMNVRDAKEKCPQLVLVNGEDLSRYREMSYKVTELLEEFSPAVERLGFDENFVDLTEMVEKRLQQLPSEEVPSVTVFGHVYNNQSVNLHNIMHRRLVVGSQIAAEMREAMYNQLGLTGCAGVAPNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKEIPGIGYKTAKRLEVLGINSVHDLQTFPIKTLEKELGIAIAQRIQQLSFGEDKSPVTPSGPPQSFSEEDTFKKCSSEVEAKAKIEELLSSLLTRVCQDGRKPHTVRLVIRRYSDKHCNRESRQCPIPSHVIQKLGTGNHDSMPPLIDILMKLFRNMVNVKMPFHLTLMSVCFCNLKALSSAKKGPMDCYLTSLSTPAYTDKRAFKVKDTHTEDSHKEKEANWDCLPSRRIESTGTGESPLDATCFPKEKDTSDLPLQALPEGVDQEVFKQLPADIQEEILYGKSRENLKGKGSLSCPLHASRGVLSFFSTKQMQASRLSPRDTALPSKRVSAASPCEPGTSGLSPGSTSHPSCGKDCSYYIDSQLKDEQTSQGPTESQGCQFSSTNPAVSGFHSFPNLQTEQLFSTHRTVDSHKQTATASHQGLESHQGLESRELDSAEEKLPFPPDIDPQVFYELPEEVQKELMAEWERAGAARPSAHR
  
Inhibitor
Name:
BDBM50356642
Synonyms:
CHEMBL1917196
Type:
Small organic molecule
Emp. Form.:
C22H28O4
Mol. Mass.:
356.4553
SMILES:
CCCCCCCCCCCC(=O)Oc1cccc2C(=O)C=CC(=O)c12 |c:21|
Structure:
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