Reaction Details Report a problem with these data
Target
Inosine-5'-monophosphate dehydrogenase
Ligand
BDBM50365455
Substrate
n/a
Meas. Tech.
ChEMBL_807432 (CHEMBL1960803)
IC50
27±n/a nM
Citation
 Kirubakaran, S; Gorla, SK; Sharling, L; Zhang, M; Liu, X; Ray, SS; Macpherson, IS; Striepen, B; Hedstrom, L; Cuny, GD Structure-activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH. Bioorg Med Chem Lett 22:1985-8 (2012) [PubMed]  Article 
Target
Name:
Inosine-5'-monophosphate dehydrogenase
Synonyms:
Cgd6_20 protein | IMDH_CRYPV | Inosine-5'-monophosphate dehydrogenase, probable | Inosine-5-monophosphate dehydrogenase (IMPDH)
Type:
Protein
Mol. Mass.:
43076.80
Organism:
Cryptosporidium parvum
Description:
Q8T6T2
Residue:
400
Sequence:
MGTKNIGKGLTFEDILLVPNYSEVLPREVSLETKLTKNVSLKIPLISSAMDTVTEHLMAVGMARLGGIGIIHKNMDMESQVNEVLKVKNWISNLEKNESTPDQNLDKESTDGKDTKSNNNIDAYSNENLDNKGRLRVGAAIGVNEIERAKLLVEAGVDVIVLDSAHGHSLNIIRTLKEIKSKMNIDVIVGNVVTEEATKELIENGADGIKVGIGPGSICTTRIVAGVGVPQITAIEKCSSVASKFGIPIIADGGIRYSGDIGKALAVGASSVMIGSILAGTEESPGEKELIGDTVYKYYRGMGSVGAMKSGSGDRYFQEKRPENKMVPEGIEGRVKYKGEMEGVVYQLVGGLRSCMGYLGSASIEELWKKSSYVEITTSGLRESHVHDVEIVKEVMNYSK
  
Inhibitor
Name:
BDBM50365455
Synonyms:
CHEMBL1231618
Type:
Small organic molecule
Emp. Form.:
C18H13BrN4OS
Mol. Mass.:
413.291
SMILES:
Brc1ccc(NC(=O)Cn2c(nc3ccccc23)-c2nccs2)cc1
Structure:
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