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Target
Peptide deformylase
Ligand
BDBM50089194
Substrate
n/a
Meas. Tech.
ChEMBL_812366 (CHEMBL2014102)
IC50
20±n/a nM
Citation
 Kwon, YJ; Sohn, MJ; Kim, CJ; Koshino, H; Kim, WG Flavimycins A and B, dimeric 1,3-dihydroisobenzofurans with peptide deformylase inhibitory activity from Aspergillus flavipes. J Nat Prod 75:271-4 (2012) [PubMed]  Article 
Target
Name:
Peptide deformylase
Synonyms:
DEF_STAAM | PDF | Polypeptide deformylase | def | def1 | pdf1
Type:
Enzyme
Mol. Mass.:
20556.80
Organism:
Staphylococcus aureus
Description:
P68825
Residue:
183
Sequence:
MLTMKDIIRDGHPTLRQKAAELELPLTKEEKETLIAMREFLVNSQDEEIAKRYGLRSGVGLAAPQINISKRMIAVLIPDDGSGKSYDYMLVNPKIVSHSVQEAYLPTGEGCLSVDDNVAGLVHRHNRITIKAKDIEGNDIQLRLKGYPAIVFQHEIDHLNGVMFYDHIDKNHPLQPHTDAVEV
  
Inhibitor
Name:
BDBM50089194
Synonyms:
(R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-2-methyl-propyl]-2-pentyl-succinamide | (R)-N4-hydroxy-N1-((S)-1-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)-2-pentylsuccinamide | ACTINONIN | CHEMBL308333 | N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-2-methyl-propyl]-2-(R)-pentyl-succinamide | N*4*-Hydroxy-N*1*-[1-(2-hydroxymethyl-pyrrolidine-1-carbonyl)-2-methyl-propyl]-2-pentyl-succinamide
Type:
Small organic molecule
Emp. Form.:
C19H35N3O5
Mol. Mass.:
385.4983
SMILES:
CCCCC[C@H](CC(=O)NO)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1CO
Structure:
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