Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50379603
Substrate
n/a
Meas. Tech.
ChEMBL_811654 (CHEMBL2014167)
Ki
0.9±n/a nM
Citation
 Wu, L; Lu, K; Packiarajan, M; Jubian, V; Chandrasena, G; Wolinsky, TC; Walker, MW Indolyl and dihydroindolyl N-glycinamides as potent and in vivo active NPY5 antagonists. Bioorg Med Chem Lett 22:2167-71 (2012) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50379603
Synonyms:
CHEMBL2013025
Type:
Small organic molecule
Emp. Form.:
C20H27F2N3O3S
Mol. Mass.:
427.508
SMILES:
CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NC(=O)Cn1ccc2cc(F)c(F)cc12 |r,wU:8.7,wD:11.14,(11.86,-7.35,;10.53,-6.58,;10.53,-5.04,;9.19,-7.34,;9.96,-8.67,;8.42,-8.67,;7.86,-6.58,;6.53,-7.34,;5.19,-6.57,;3.87,-7.34,;2.54,-6.57,;2.54,-5.03,;3.87,-4.25,;5.19,-5.03,;1.2,-4.27,;-.13,-5.04,;-.13,-6.58,;-1.47,-4.27,;-2.8,-5.05,;-2.96,-6.58,;-4.47,-6.9,;-5.24,-5.57,;-6.74,-5.26,;-7.22,-3.8,;-8.73,-3.49,;-6.19,-2.65,;-6.67,-1.18,;-4.69,-2.97,;-4.21,-4.43,)|
Structure:
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