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Target
D(2) dopamine receptor
Ligand
BDBM50380565
Substrate
n/a
Meas. Tech.
ChEMBL_813150 (CHEMBL2020816)
IC50
44.67±n/a nM
Citation
 McRobb, FM; Crosby, IT; Yuriev, E; Lane, JR; Capuano, B Homobivalent ligands of the atypical antipsychotic clozapine: design, synthesis, and pharmacological evaluation. J Med Chem 55:1622-34 (2012) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50380565
Synonyms:
CHEMBL2016628
Type:
Small organic molecule
Emp. Form.:
C50H62Cl2N10O2
Mol. Mass.:
905.999
SMILES:
Clc1ccc2Nc3ccccc3C(=Nc2c1)N1CCN(CCCNC(=O)CCCCCCCCC(=O)NCCCN2CCN(CC2)C2=Nc3cc(Cl)ccc3Nc3ccccc23)CC1 |c:13,t:50|
Structure:
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