Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase receptor TYRO3
Ligand
BDBM50380786
Substrate
n/a
Meas. Tech.
ChEMBL_813619 (CHEMBL2019768)
IC50
100±n/a nM
Citation
 Forns, P; Esteve, C; Taboada, L; Alonso, JA; Orellana, A; Maldonado, M; Carreño, C; Ramis, I; López, M; Miralpeix, M; Vidal, B Pyrazine-based Syk kinase inhibitors. Bioorg Med Chem Lett 22:2784-8 (2012) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase receptor TYRO3
Synonyms:
BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY
Type:
Protein
Mol. Mass.:
96894.13
Organism:
Homo sapiens (Human)
Description:
Q06418
Residue:
890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
  
Inhibitor
Name:
BDBM50380786
Synonyms:
CHEMBL2018018
Type:
Small organic molecule
Emp. Form.:
C22H24N6O2
Mol. Mass.:
404.465
SMILES:
Nc1ncc(nc1C(=O)N[C@H]1C2CC3CC1C[C@@](O)(C3)C2)-c1ccc2cn[nH]c2c1 |r,wU:10.10,17.19,TLB:14:15:20:12.13.19,14:13:10.15.16:20,18:17:10:12.14.13,THB:9:10:12.14.13:16.17.20,9:10:20:12.13.19,19:13:10:16.17.20,19:17:10:12.14.13,(-3.17,-5.41,;-3.23,-3.88,;-4.59,-3.16,;-4.65,-1.62,;-3.34,-.8,;-1.98,-1.51,;-1.92,-3.05,;-.56,-3.76,;-.49,-5.3,;.74,-2.94,;2.11,-3.64,;3.28,-2.34,;4.61,-2.8,;6,-2.42,;5.02,-3.72,;3.6,-3.19,;3.56,-1.61,;4.57,-.35,;4.56,1.19,;5.98,-.9,;3.24,-.86,;-3.4,.73,;-2.09,1.56,;-2.15,3.1,;-3.51,3.81,;-3.89,5.31,;-5.43,5.41,;-6,3.98,;-4.82,2.99,;-4.76,1.45,)|
Structure:
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