Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase receptor TYRO3
Ligand
BDBM50380788
Substrate
n/a
Meas. Tech.
ChEMBL_813619 (CHEMBL2019768)
IC50
50±n/a nM
Citation
 Forns, P; Esteve, C; Taboada, L; Alonso, JA; Orellana, A; Maldonado, M; Carreño, C; Ramis, I; López, M; Miralpeix, M; Vidal, B Pyrazine-based Syk kinase inhibitors. Bioorg Med Chem Lett 22:2784-8 (2012) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase receptor TYRO3
Synonyms:
BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY
Type:
Protein
Mol. Mass.:
96894.13
Organism:
Homo sapiens (Human)
Description:
Q06418
Residue:
890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
  
Inhibitor
Name:
BDBM50380788
Synonyms:
CHEMBL2018020
Type:
Small organic molecule
Emp. Form.:
C24H26N6O2
Mol. Mass.:
430.5022
SMILES:
Nc1ncc(nc1C(=O)N[C@H]1C2CC3CC1C[C@@](O)(C3)C2)-c1cccc(c1)-c1cn[nH]c1 |r,wU:10.10,17.19,TLB:14:15:20:12.13.19,14:13:10.15.16:20,18:17:10:12.14.13,THB:9:10:12.14.13:16.17.20,9:10:20:12.13.19,19:13:10:16.17.20,19:17:10:12.14.13,(31.51,-20.45,;31.45,-18.91,;30.09,-18.19,;30.03,-16.65,;31.33,-15.83,;32.69,-16.54,;32.76,-18.08,;34.12,-18.79,;34.19,-20.33,;35.42,-17.97,;36.79,-18.68,;37.96,-17.37,;39.29,-17.83,;40.68,-17.46,;39.7,-18.76,;38.28,-18.22,;38.24,-16.64,;39.25,-15.38,;39.24,-13.84,;40.66,-15.93,;37.91,-15.89,;31.28,-14.3,;32.59,-13.47,;32.53,-11.93,;31.17,-11.22,;29.86,-12.04,;29.91,-13.58,;28.49,-11.32,;27.1,-12,;26.03,-10.89,;26.75,-9.53,;28.27,-9.79,)|
Structure:
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