Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase receptor TYRO3
Ligand
BDBM50380790
Substrate
n/a
Meas. Tech.
ChEMBL_813619 (CHEMBL2019768)
IC50
30±n/a nM
Citation
 Forns, P; Esteve, C; Taboada, L; Alonso, JA; Orellana, A; Maldonado, M; Carreño, C; Ramis, I; López, M; Miralpeix, M; Vidal, B Pyrazine-based Syk kinase inhibitors. Bioorg Med Chem Lett 22:2784-8 (2012) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase receptor TYRO3
Synonyms:
BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY
Type:
Protein
Mol. Mass.:
96894.13
Organism:
Homo sapiens (Human)
Description:
Q06418
Residue:
890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
  
Inhibitor
Name:
BDBM50380790
Synonyms:
CHEMBL2018023
Type:
Small organic molecule
Emp. Form.:
C26H30N6O2
Mol. Mass.:
458.5554
SMILES:
Cc1cc(cc(c1)-c1cnc(N)c(n1)C(=O)N[C@H]1C2CC3CC1C[C@@](O)(C3)C2)-c1cnn(C)c1 |r,wU:17.18,24.27,TLB:21:22:27:19.20.26,21:20:17.22.23:27,25:24:17:19.21.20,THB:16:17:19.21.20:23.24.27,16:17:27:19.20.26,26:20:17:23.24.27,26:24:17:19.21.20,(.72,-40.49,;-.58,-41.31,;-1.94,-40.59,;-3.25,-41.41,;-3.2,-42.95,;-1.83,-43.68,;-.52,-42.85,;-1.78,-45.21,;-3.08,-46.03,;-3.02,-47.57,;-1.66,-48.29,;-1.6,-49.82,;-.35,-47.46,;-.42,-45.92,;1.01,-48.17,;1.08,-49.71,;2.31,-47.34,;3.68,-48.05,;4.85,-46.75,;6.18,-47.21,;7.57,-46.83,;6.59,-48.13,;5.17,-47.6,;5.13,-46.02,;6.14,-44.76,;6.13,-43.21,;7.55,-45.31,;4.8,-45.27,;-4.62,-40.7,;-6.01,-41.37,;-7.08,-40.26,;-6.36,-38.9,;-7.03,-37.52,;-4.84,-39.17,)|
Structure:
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