Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase receptor TYRO3
Ligand
BDBM50380791
Substrate
n/a
Meas. Tech.
ChEMBL_813619 (CHEMBL2019768)
IC50
50±n/a nM
Citation
 Forns, P; Esteve, C; Taboada, L; Alonso, JA; Orellana, A; Maldonado, M; Carreño, C; Ramis, I; López, M; Miralpeix, M; Vidal, B Pyrazine-based Syk kinase inhibitors. Bioorg Med Chem Lett 22:2784-8 (2012) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase receptor TYRO3
Synonyms:
BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY
Type:
Protein
Mol. Mass.:
96894.13
Organism:
Homo sapiens (Human)
Description:
Q06418
Residue:
890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
  
Inhibitor
Name:
BDBM50380791
Synonyms:
CHEMBL2018024
Type:
Small organic molecule
Emp. Form.:
C26H30N6O3
Mol. Mass.:
474.5548
SMILES:
COc1cc(cc(c1)-c1cnc(N)c(n1)C(=O)N[C@H]1C2CC3CC1C[C@@](O)(C3)C2)-c1cnn(C)c1 |r,wU:18.19,25.28,TLB:22:23:28:20.21.27,22:21:18.23.24:28,26:25:18:20.22.21,THB:17:18:20.22.21:24.25.28,17:18:28:20.21.27,27:21:18:24.25.28,27:25:18:20.22.21,(1.83,2.47,;.47,3.18,;-.83,2.36,;-2.19,3.08,;-3.5,2.26,;-3.44,.72,;-2.08,-0,;-.77,.83,;-2.02,-1.54,;-3.33,-2.36,;-3.27,-3.89,;-1.91,-4.61,;-1.85,-6.15,;-.6,-3.78,;-.67,-2.25,;.76,-4.5,;.83,-6.04,;2.06,-3.67,;3.43,-4.38,;4.6,-3.08,;5.94,-3.54,;7.32,-3.16,;6.34,-4.46,;4.92,-3.93,;4.88,-2.34,;5.89,-1.09,;5.88,.46,;7.3,-1.63,;4.56,-1.59,;-4.87,2.98,;-6.25,2.3,;-7.32,3.41,;-6.6,4.77,;-7.28,6.15,;-5.09,4.5,)|
Structure:
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