Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase receptor TYRO3
Ligand
BDBM50380793
Substrate
n/a
Meas. Tech.
ChEMBL_813619 (CHEMBL2019768)
IC50
50±n/a nM
Citation
 Forns, P; Esteve, C; Taboada, L; Alonso, JA; Orellana, A; Maldonado, M; Carreño, C; Ramis, I; López, M; Miralpeix, M; Vidal, B Pyrazine-based Syk kinase inhibitors. Bioorg Med Chem Lett 22:2784-8 (2012) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase receptor TYRO3
Synonyms:
BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY
Type:
Protein
Mol. Mass.:
96894.13
Organism:
Homo sapiens (Human)
Description:
Q06418
Residue:
890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
  
Inhibitor
Name:
BDBM50380793
Synonyms:
CHEMBL2018026
Type:
Small organic molecule
Emp. Form.:
C26H27F3N6O2
Mol. Mass.:
512.5268
SMILES:
Nc1ncc(nc1C(=O)N[C@H]1C2CC3CC1C[C@@](O)(C3)C2)-c1cccc(c1)-c1cnn(CC(F)(F)F)c1 |r,wU:10.10,17.19,TLB:18:17:10:12.14.13,14:15:20:12.13.19,14:13:10.15.16:20,THB:19:13:10:16.17.20,19:17:10:12.14.13,9:10:12.14.13:16.17.20,9:10:20:12.13.19,(-.48,-7.03,;-.54,-5.49,;-1.91,-4.77,;-1.96,-3.24,;-.66,-2.42,;.7,-3.13,;.76,-4.66,;2.13,-5.38,;2.19,-6.92,;3.43,-4.55,;4.8,-5.26,;5.96,-3.96,;7.3,-4.42,;8.69,-4.04,;7.7,-5.34,;6.29,-4.81,;6.25,-3.22,;7.26,-1.97,;7.25,-.42,;8.67,-2.51,;5.92,-2.47,;-.71,-.88,;.6,-.06,;.53,1.48,;-.83,2.2,;-2.14,1.38,;-2.08,-.16,;-3.41,2.25,;-4.87,1.77,;-5.78,3.01,;-4.88,4.26,;-5.61,5.62,;-7.15,5.67,;-7.87,7.03,;-7.96,4.37,;-8.69,5.68,;-3.42,3.79,)|
Structure:
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