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Target
Tyrosine-protein kinase receptor TYRO3
Ligand
BDBM50380799
Substrate
n/a
Meas. Tech.
ChEMBL_813619 (CHEMBL2019768)
IC50
40±n/a nM
Citation
 Forns, P; Esteve, C; Taboada, L; Alonso, JA; Orellana, A; Maldonado, M; Carreño, C; Ramis, I; López, M; Miralpeix, M; Vidal, B Pyrazine-based Syk kinase inhibitors. Bioorg Med Chem Lett 22:2784-8 (2012) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase receptor TYRO3
Synonyms:
BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY
Type:
Protein
Mol. Mass.:
96894.13
Organism:
Homo sapiens (Human)
Description:
Q06418
Residue:
890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
  
Inhibitor
Name:
BDBM50380799
Synonyms:
CHEMBL2018032
Type:
Small organic molecule
Emp. Form.:
C26H29N7O3
Mol. Mass.:
487.5536
SMILES:
NC(=O)Cn1cc(cn1)-c1cccc(c1)-c1cnc(N)c(n1)C(=O)N[C@H]1C2CC3CC1C[C@@](O)(C3)C2 |r,wU:25.27,32.36,TLB:29:30:35:27.28.34,29:28:25.30.31:35,33:32:25:27.29.28,THB:34:28:25:31.32.35,34:32:25:27.29.28,24:25:27.29.28:31.32.35,24:25:35:27.28.34,(-8.36,6.94,;-7.56,5.63,;-8.29,4.28,;-6.02,5.67,;-5.21,4.35,;-3.75,3.88,;-3.74,2.34,;-5.2,1.86,;-6.12,3.1,;-2.47,1.47,;-1.16,2.29,;.2,1.57,;.26,.03,;-1.05,-.79,;-2.41,-.07,;-.99,-2.33,;-2.3,-3.15,;-2.24,-4.68,;-.87,-5.4,;-.81,-6.94,;.43,-4.58,;.37,-3.04,;1.8,-5.29,;1.86,-6.83,;3.1,-4.46,;4.46,-5.17,;5.63,-3.87,;6.97,-4.33,;8.36,-3.95,;7.37,-5.25,;5.96,-4.72,;5.92,-3.14,;6.93,-1.88,;6.92,-.33,;8.34,-2.42,;5.59,-2.39,)|
Structure:
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