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Target
Tyrosine-protein kinase receptor TYRO3
Ligand
BDBM50380800
Substrate
n/a
Meas. Tech.
ChEMBL_813619 (CHEMBL2019768)
IC50
60±n/a nM
Citation
 Forns, P; Esteve, C; Taboada, L; Alonso, JA; Orellana, A; Maldonado, M; Carreño, C; Ramis, I; López, M; Miralpeix, M; Vidal, B Pyrazine-based Syk kinase inhibitors. Bioorg Med Chem Lett 22:2784-8 (2012) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase receptor TYRO3
Synonyms:
BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY
Type:
Protein
Mol. Mass.:
96894.13
Organism:
Homo sapiens (Human)
Description:
Q06418
Residue:
890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
  
Inhibitor
Name:
BDBM50380800
Synonyms:
CHEMBL2018143
Type:
Small organic molecule
Emp. Form.:
C27H32N6O3
Mol. Mass.:
488.5814
SMILES:
COCCn1cc(cn1)-c1cccc(c1)-c1cnc(N)c(n1)C(=O)N[C@H]1C2CC3CC1C[C@@](O)(C3)C2 |r,wU:25.27,32.36,TLB:29:30:35:27.28.34,29:28:25.30.31:35,33:32:25:27.29.28,THB:34:28:25:31.32.35,34:32:25:27.29.28,24:25:27.29.28:31.32.35,24:25:35:27.28.34,(-9.1,4.88,;-7.56,4.91,;-6.82,6.27,;-5.28,6.3,;-4.48,4.99,;-3.01,4.52,;-3,2.98,;-4.47,2.5,;-5.38,3.74,;-1.73,2.11,;-.42,2.92,;.94,2.21,;1,.67,;-.31,-.16,;-1.67,.57,;-.25,-1.69,;-1.56,-2.51,;-1.5,-4.05,;-.14,-4.77,;-.08,-6.3,;1.17,-3.94,;1.11,-2.4,;2.54,-4.65,;2.6,-6.19,;3.84,-3.83,;5.2,-4.53,;6.37,-3.23,;7.71,-3.69,;9.1,-3.31,;8.11,-4.61,;6.69,-4.08,;6.65,-2.5,;7.66,-1.24,;7.65,.31,;9.07,-1.79,;6.33,-1.75,)|
Structure:
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