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Target
Tyrosine-protein kinase receptor TYRO3
Ligand
BDBM50380802
Substrate
n/a
Meas. Tech.
ChEMBL_813619 (CHEMBL2019768)
IC50
20±n/a nM
Citation
 Forns, P; Esteve, C; Taboada, L; Alonso, JA; Orellana, A; Maldonado, M; Carreño, C; Ramis, I; López, M; Miralpeix, M; Vidal, B Pyrazine-based Syk kinase inhibitors. Bioorg Med Chem Lett 22:2784-8 (2012) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase receptor TYRO3
Synonyms:
BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY
Type:
Protein
Mol. Mass.:
96894.13
Organism:
Homo sapiens (Human)
Description:
Q06418
Residue:
890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
  
Inhibitor
Name:
BDBM50380802
Synonyms:
CHEMBL2018145
Type:
Small organic molecule
Emp. Form.:
C25H28N6O2
Mol. Mass.:
444.5288
SMILES:
Cn1cc(cn1)-c1cccc(c1)-c1cnc(N)c(n1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 |r,wU:29.33,wD:22.24,TLB:30:29:22:26.24.25,21:22:28:26.25.31,THB:24:23:28:26.25.31,24:25:22.23.32:28,31:25:22:32.29.28,31:29:22:26.24.25,(-9.26,-3.44,;-7.71,-3.48,;-6.77,-2.25,;-5.32,-2.76,;-5.35,-4.3,;-6.83,-4.74,;-4.05,-1.88,;-4.02,-.34,;-2.69,.41,;-1.36,-.37,;-1.38,-1.92,;-2.73,-2.67,;-.06,-2.7,;-.08,-4.25,;1.24,-5.03,;2.59,-4.28,;3.91,-5.06,;2.6,-2.73,;1.28,-1.95,;3.94,-1.97,;5.27,-2.76,;3.95,-.43,;5.28,.33,;6.78,.72,;8.18,.13,;9.22,1.39,;7.81,1.07,;6.5,1.58,;6.51,3.07,;7.87,3.52,;7.92,5.06,;9.26,2.92,;6.81,2.3,)|
Structure:
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