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Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM50385360
Substrate
n/a
Meas. Tech.
ChEMBL_822749 (CHEMBL2040233)
IC50
4400±n/a nM
Citation
 Banoglu, E; Çaliskan, B; Luderer, S; Eren, G; Özkan, Y; Altenhofen, W; Weinigel, C; Barz, D; Gerstmeier, J; Pergola, C; Werz, O Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP). Bioorg Med Chem 20:3728-41 (2012) [PubMed]  Article 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM50385360
Synonyms:
CHEMBL2036187
Type:
Small organic molecule
Emp. Form.:
C26H26Cl2N2
Mol. Mass.:
437.404
SMILES:
CC(C)Cc1ccc(cc1)C(C)c1nc2ccccc2n1Cc1c(Cl)cccc1Cl
Structure:
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