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Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM50385382
Substrate
n/a
Meas. Tech.
ChEMBL_822749 (CHEMBL2040233)
IC50
9400±n/a nM
Citation
 Banoglu, E; Çaliskan, B; Luderer, S; Eren, G; Özkan, Y; Altenhofen, W; Weinigel, C; Barz, D; Gerstmeier, J; Pergola, C; Werz, O Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP). Bioorg Med Chem 20:3728-41 (2012) [PubMed]  Article 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM50385382
Synonyms:
CHEMBL2036189
Type:
Small organic molecule
Emp. Form.:
C29H34N2O3
Mol. Mass.:
458.5919
SMILES:
COc1ccc(Cn2c(nc3ccccc23)C(C)c2ccc(CC(C)C)cc2)c(OC)c1OC
Structure:
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