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Target
Subtilisin-like protease 1
Ligand
BDBM50388062
Substrate
n/a
Meas. Tech.
ChEMBL_830092 (CHEMBL2061883)
IC50
40000±n/a nM
Citation
 Gemma, S; Giovani, S; Brindisi, M; Tripaldi, P; Brogi, S; Savini, L; Fiorini, I; Novellino, E; Butini, S; Campiani, G; Penzo, M; Blackman, MJ Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1. Bioorg Med Chem Lett 22:5317-21 (2012) [PubMed]  Article 
Target
Name:
Subtilisin-like protease 1
Synonyms:
SUB1 | SUB1_PLAFA | Subtilisin-like protease | Subtilisin-like serine protease | sub-1
Type:
PROTEIN
Mol. Mass.:
77866.88
Organism:
Plasmodium falciparum
Description:
ChEMBL_830092
Residue:
690
Sequence:
MMLNKKVVALCTLTLHLFCIFLCLGKEVRSEENGKIQDDAKKIVSELRFLEKVEDVIEKSNIGGNEVDADENSFNPDTEVPIEEIEEIKMRELKDVKEEKNKNDNHNNNNNNNNISSSSSSSSNTFGEEKEEVSKKKKKLRLIVSENHATTPSFFQESLLEPDVLSFLESKGNLSNLKNINSMIIELKEDTTDDELISYIKILEEKGALIESDKLVSADNIDISGIKDAIRRGEENIDVNDYKSMLEVENDAEDYDKMFGMFNESHAATSKRKRHSTNERGYDTFSSPSYKTYSKSDYLYDDDNNNNNYYYSHSSNGHNSSSRNSSSSRSRPGKYHFNDEFRNLQWGLDLSRLDETQELINEHQVMSTRICVIDSGIDYNHPDLKDNIELNLKELHGRKGFDDDNNGIVDDIYGANFVNNSGNPMDDNYHGTHVSGIISAIGNNNIGVVGVDVNSKLIICKALDEHKLGRLGDMFKCLDYCISRNAHMINGSFSFDEYSGIFNSSVEYLQRKGILFFVSASNCSHPKSSTPDIRKCDLSINAKYPPILSTVYDNVISVANLKKNDNNNHYSLSINSFYSNKYCQLAAPGTNIYSTAPHNSYRKLNGTSMAAPHVAAIASLIFSINPDLSYKKVIQILKDSIVYLPSLKNMVAWAGYADINKAVNLAIKSKKTYINSNISNKWKKKSRYLH
  
Inhibitor
Name:
BDBM50388062
Synonyms:
CHEMBL2059472
Type:
Small organic molecule
Emp. Form.:
C19H14N4O2
Mol. Mass.:
330.3401
SMILES:
Cc1cc(N=NCc2ccc(cc2)C#N)c2cc3OCOc3cc2n1 |w:4.3|
Structure:
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