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Target
DNA-(apurinic or apyrimidinic site) endonuclease
Ligand
BDBM83759
Substrate
n/a
Meas. Tech.
ChEMBL_829705 (CHEMBL2061145)
IC50
1500±n/a nM
Citation
 Rai, G; Vyjayanti, VN; Dorjsuren, D; Simeonov, A; Jadhav, A; Wilson, DM; Maloney, DJ Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors. J Med Chem 55:3101-12 (2012) [PubMed]  Article 
Target
Name:
DNA-(apurinic or apyrimidinic site) endonuclease
Synonyms:
APE | APE1 | APEX | APEX1 | APEX1_HUMAN | APX | Apurinic-apyrimidinic endonuclease 1 (APE-1) | Apurinic/apyrimidinic endonuclease 1 (APE1) | DNA-(apurinic or apyrimidinic site) lyase | HAP1 | REF1
Type:
Protein
Mol. Mass.:
35560.12
Organism:
Homo sapiens (Human)
Description:
P27695
Residue:
318
Sequence:
MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL
  
Inhibitor
Name:
BDBM83759
Synonyms:
(2,4,9-trimethylbenzo[b][1,8]naphthyridin-5-yl)amine | 2,4,9-Trimethyl-benzo[b][1,8]naphthyridin-5-ylamine | 2,4,9-trimethyl-5-benzo[b][1,8]naphthyridinamine | 2,4,9-trimethylbenzo[b][1,8]naphthyridin-5-amine | MLS000552981 | SMR000178181 | cid_698490
Type:
Small organic molecule
Emp. Form.:
C15H15N3
Mol. Mass.:
237.2997
SMILES:
Cc1cc(C)c2c(N)c3cccc(C)c3nc2n1
Structure:
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