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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50388674
Substrate
n/a
Meas. Tech.
ChEMBL_829274 (CHEMBL2060121)
EC50
400±n/a nM
Citation
 Sams, AG; Larsen, K; Mikkelsen, GK; Hentzer, M; Christoffersen, CT; Jensen, KG; Frederiksen, K; Bang-Andersen, B Hit-to-lead investigation of a series of novel combined dopamine D2 and muscarinic M1 receptor ligands with putative antipsychotic and pro-cognitive potential. Bioorg Med Chem Lett 22:5134-40 (2012) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50388674
Synonyms:
OXIPEROMIDE
Type:
Small organic molecule
Emp. Form.:
C20H23N3O2
Mol. Mass.:
337.4155
SMILES:
O=c1[nH]c2ccccc2n1C1CCN(CCOc2ccccc2)CC1
Structure:
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