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Target
Casein kinase I isoform gamma-2
Ligand
BDBM50390497
Substrate
n/a
Meas. Tech.
ChEMBL_835304 (CHEMBL2072010)
IC50
1450±n/a nM
Citation
 Hua, Z; Huang, X; Bregman, H; Chakka, N; DiMauro, EF; Doherty, EM; Goldstein, J; Gunaydin, H; Huang, H; Mercede, S; Newcomb, J; Patel, VF; Turci, SM; Yan, J; Wilson, C; Martin, MW 2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1¿) inhibitors. Bioorg Med Chem Lett 22:5392-5 (2012) [PubMed]  Article 
Target
Name:
Casein kinase I isoform gamma-2
Synonyms:
CK1G2 | CSNK1G2 | Casein kinase I | Casein kinase I gamma 2 | KC1G2_HUMAN
Type:
PROTEIN
Mol. Mass.:
47475.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774313
Residue:
415
Sequence:
MDFDKKGGKGETEEGRRMSKAGGGRSSHGIRSSGTSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGFVFDYEYDWAGKPLPTPIGTVHTDLPSQPQLRDKTQPHSKNQALNSTNGELNADDPTAGHSNAPITAPAEVEVADETKCCCFFKRRKRKSLQRHK
  
Inhibitor
Name:
BDBM50390497
Synonyms:
CHEMBL2071611
Type:
Small organic molecule
Emp. Form.:
C18H14N6
Mol. Mass.:
314.344
SMILES:
Cn1cc(cn1)-c1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1
Structure:
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