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Target
Sodium- and chloride-dependent glycine transporter 1
Ligand
BDBM50391747
Substrate
n/a
Meas. Tech.
ChEMBL_849525 (CHEMBL2149632)
IC50
7.3±n/a nM
Citation
Blackaby, WP; Lewis, RT; Thomson, JL; Jennings, AS; Goodacre, SC; Street, LJ; MacLeod, AM; Pike, A; Wood, S; Thomas, S; Brown, TA; Smith, A; Pillai, G; Almond, S; Guscott, MR; Burns, HD; Eng, W; Ryan, C; Cook, J; Hamill, TG Identification of an Orally Bioavailable, Potent, and Selective Inhibitor of GlyT1. ACS Med Chem Lett 1:350-354 (2010) [PubMed] Article
More Info.:
Target
Name:
Sodium- and chloride-dependent glycine transporter 1
Synonyms:
GlyT-1 | GlyT1 | Glycine Transporters (GlyT1c) | Glycine transporter 1 | SC6A9_HUMAN | SLC6A9 | Sodium- and chloride-dependent glycine transporter 1 | Sodium- and chloride-dependent glycine transporter 1 (GlyT1) | Sodium- and chloride-dependent glycine transporter 1 (GlyT1c) | Sodium-and chloride-dependent glycine transporter 1 (GlyT-1c) | Solute carrier family 6 member 9
Type:
Enzyme
Mol. Mass.:
78270.54
Organism:
Homo sapiens (Human)
Description:
P48067
Residue:
706
Sequence:
MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKVWHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
Inhibitor
Name:
BDBM50391747
Synonyms:
CHEMBL2146711
Type:
Small organic molecule
Emp. Form.:
C22H26Cl2N2O4S
Mol. Mass.:
485.424
SMILES:
Cc1cc(no1)S(=O)(=O)[C@H]1CC[C@](CNC(=O)c2ccc(Cl)cc2Cl)(CC2CC2)CC1 |r,wU:9.9,12.13,wD:12.26,(-1.11,-33.46,;-1.63,-32.01,;-3.1,-31.57,;-3.13,-30.04,;-1.69,-29.53,;-.75,-30.75,;-4.31,-29.05,;-5.86,-29.04,;-5.09,-30.38,;-4.31,-27.51,;-5.64,-26.75,;-5.64,-25.21,;-4.31,-24.43,;-3.02,-23.59,;-1.65,-24.29,;-.3,-23.54,;-.28,-22,;1.02,-24.32,;.99,-25.86,;2.31,-26.65,;3.66,-25.89,;4.98,-26.68,;3.68,-24.35,;2.35,-23.57,;2.37,-22.03,;-5.38,-23.3,;-6.88,-23.66,;-8.35,-23.21,;-8,-24.71,;-2.98,-25.21,;-2.98,-26.75,)|