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Target
Sodium- and chloride-dependent glycine transporter 1
Ligand
BDBM50391754
Substrate
n/a
Meas. Tech.
ChEMBL_849525 (CHEMBL2149632)
IC50
1627±n/a nM
Citation
 Blackaby, WP; Lewis, RT; Thomson, JL; Jennings, AS; Goodacre, SC; Street, LJ; MacLeod, AM; Pike, A; Wood, S; Thomas, S; Brown, TA; Smith, A; Pillai, G; Almond, S; Guscott, MR; Burns, HD; Eng, W; Ryan, C; Cook, J; Hamill, TG Identification of an Orally Bioavailable, Potent, and Selective Inhibitor of GlyT1. ACS Med Chem Lett 1:350-354 (2010) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent glycine transporter 1
Synonyms:
GlyT-1 | GlyT1 | Glycine Transporters (GlyT1c) | Glycine transporter 1 | SC6A9_HUMAN | SLC6A9 | Sodium- and chloride-dependent glycine transporter 1 | Sodium- and chloride-dependent glycine transporter 1 (GlyT1) | Sodium- and chloride-dependent glycine transporter 1 (GlyT1c) | Sodium-and chloride-dependent glycine transporter 1 (GlyT-1c) | Solute carrier family 6 member 9
Type:
Enzyme
Mol. Mass.:
78270.54
Organism:
Homo sapiens (Human)
Description:
P48067
Residue:
706
Sequence:
MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKVWHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
  
Inhibitor
Name:
BDBM50391754
Synonyms:
CHEMBL2146718
Type:
Small organic molecule
Emp. Form.:
C21H29Cl2NO3S
Mol. Mass.:
446.431
SMILES:
CCCS(=O)(=O)[C@H]1CC[C@@](CNC(=O)c2ccc(Cl)cc2Cl)(CC2CC2)CC1 |r,wU:9.22,6.5,wD:9.9,(19.26,-16.28,;17.96,-15.45,;16.59,-16.16,;15.3,-15.34,;13.75,-15.33,;14.51,-16.67,;15.3,-13.8,;13.97,-13.04,;13.97,-11.5,;15.3,-10.72,;16.59,-9.88,;17.96,-10.58,;19.31,-9.83,;19.33,-8.29,;20.63,-10.61,;20.6,-12.15,;21.92,-12.94,;23.27,-12.18,;24.59,-12.97,;23.29,-10.63,;21.96,-9.85,;21.97,-8.31,;14.23,-9.59,;12.73,-9.95,;11.26,-9.5,;11.61,-11,;16.63,-11.5,;16.63,-13.04,)|
Structure:
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