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Target
Glucagon-like peptide 1 receptor
Ligand
BDBM50393564
Substrate
n/a
Meas. Tech.
ChEMBL_855309 (CHEMBL2161793)
EC50
>20000±n/a nM
Citation
 Liu, Q; Li, N; Yuan, Y; Lu, H; Wu, X; Zhou, C; He, M; Su, H; Zhang, M; Wang, J; Wang, B; Wang, Y; Ma, D; Ye, Y; Weiss, HC; Gesing, ER; Liao, J; Wang, MW Cyclobutane derivatives as novel nonpeptidic small molecule agonists of glucagon-like peptide-1 receptor. J Med Chem 55:250-67 (2012) [PubMed]  Article 
Target
Name:
Glucagon-like peptide 1 receptor
Synonyms:
GLP1R_RAT | Glp1r | Glpr
Type:
PROTEIN
Mol. Mass.:
52889.73
Organism:
Rattus norvegicus
Description:
ChEMBL_855307
Residue:
463
Sequence:
MAVTPSLLRLALLLLGAVGRAGPRPQGATVSLSETVQKWREYRHQCQRFLTEAPLLATGLFCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGIWLHKDNSSLPWRDLSECEESKQGERNSPEEQLLSLYIIYTVGYALSFSALVIASAILVSFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLVFIRVICIVIAKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFVKLFTELSFTSFQGFMVAVLYCFVNNEVQMEFRKSWERWRLERLNIQRDSSMKPLKCPTSSVSSGATVGSSVYAATCQNSCS
  
Inhibitor
Name:
BDBM50393564
Synonyms:
CHEMBL2158392
Type:
Small organic molecule
Emp. Form.:
C42H44N4O10
Mol. Mass.:
764.8196
SMILES:
CC(C)(C)OC(=O)Nc1ccc(cc1)C(=O)N[C@@]1([C@H](c2ccccc2)[C@](NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)([C@@H]1c1ccccc1)C(O)=O)C(O)=O |r,wU:18.19,25.27,43.47,17.17,wD:25.54,17.57,(30.33,-18.46,;31.67,-17.7,;33,-18.48,;31.68,-19.24,;31.68,-16.16,;33.02,-15.4,;34.35,-16.18,;33.03,-13.86,;31.7,-13.08,;30.36,-13.84,;29.03,-13.06,;29.05,-11.52,;30.38,-10.76,;31.71,-11.53,;27.73,-10.74,;26.39,-11.5,;27.74,-9.2,;26.67,-8.09,;26.67,-6.55,;27.99,-5.76,;29.33,-6.51,;30.65,-5.72,;30.62,-4.17,;29.27,-3.43,;27.95,-4.22,;25.13,-6.55,;24.36,-5.22,;25.13,-3.88,;26.67,-3.88,;24.36,-2.55,;25.13,-1.22,;24.36,.11,;22.82,.11,;22.05,1.44,;22.81,2.78,;22.04,4.11,;24.35,2.78,;25.12,4.12,;26.66,4.12,;24.35,5.45,;25.88,5.46,;22.05,-1.23,;22.82,-2.56,;25.13,-8.09,;24.34,-9.39,;22.79,-9.36,;21.99,-10.67,;22.72,-12.02,;24.27,-12.06,;25.06,-10.73,;23.58,-6.55,;22.81,-5.22,;22.81,-7.89,;28.2,-8.09,;28.97,-9.42,;28.72,-7.03,)|
Structure:
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