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Target
Glucagon-like peptide 1 receptor
Ligand
BDBM50393597
Substrate
n/a
Meas. Tech.
ChEMBL_855307 (CHEMBL2161791)
IC50
>20000±n/a nM
Citation
 Liu, Q; Li, N; Yuan, Y; Lu, H; Wu, X; Zhou, C; He, M; Su, H; Zhang, M; Wang, J; Wang, B; Wang, Y; Ma, D; Ye, Y; Weiss, HC; Gesing, ER; Liao, J; Wang, MW Cyclobutane derivatives as novel nonpeptidic small molecule agonists of glucagon-like peptide-1 receptor. J Med Chem 55:250-67 (2012) [PubMed]  Article 
Target
Name:
Glucagon-like peptide 1 receptor
Synonyms:
GLP1R_RAT | Glp1r | Glpr
Type:
PROTEIN
Mol. Mass.:
52889.73
Organism:
Rattus norvegicus
Description:
ChEMBL_855307
Residue:
463
Sequence:
MAVTPSLLRLALLLLGAVGRAGPRPQGATVSLSETVQKWREYRHQCQRFLTEAPLLATGLFCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGIWLHKDNSSLPWRDLSECEESKQGERNSPEEQLLSLYIIYTVGYALSFSALVIASAILVSFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLVFIRVICIVIAKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFVKLFTELSFTSFQGFMVAVLYCFVNNEVQMEFRKSWERWRLERLNIQRDSSMKPLKCPTSSVSSGATVGSSVYAATCQNSCS
  
Inhibitor
Name:
BDBM50393597
Synonyms:
CHEMBL2158394
Type:
Small organic molecule
Emp. Form.:
C48H56N4O12
Mol. Mass.:
880.9778
SMILES:
CCCOc1ccc(cc1)[C@H]1[C@@](NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)([C@@H](c2ccc(OCCC)cc2)[C@]1(NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(O)=O)C(O)=O |r,wU:10.10,40.44,29.31,11.12,wD:40.62,11.65,(34.55,-25.37,;34.58,-26.91,;33.26,-27.7,;33.29,-29.24,;31.97,-30.04,;31.99,-31.58,;30.67,-32.37,;29.33,-31.62,;29.3,-30.08,;30.61,-29.29,;28.02,-32.41,;28.01,-33.95,;29.08,-35.06,;29.07,-36.6,;27.73,-37.36,;30.4,-37.38,;30.38,-38.92,;31.71,-39.7,;33.05,-38.94,;34.38,-39.72,;34.37,-41.26,;35.69,-42.04,;33.03,-42.02,;33.02,-43.56,;31.68,-44.32,;34.35,-44.34,;33.02,-45.1,;33.05,-37.39,;31.73,-36.62,;26.48,-33.95,;25.68,-35.25,;24.13,-35.22,;23.33,-36.53,;24.07,-37.88,;23.27,-39.2,;21.73,-39.16,;20.93,-40.48,;19.39,-40.44,;25.62,-37.92,;26.41,-36.6,;26.47,-32.41,;25.7,-31.08,;26.47,-29.74,;28.01,-29.74,;25.7,-28.41,;26.47,-27.08,;25.71,-25.75,;24.16,-25.75,;23.39,-24.42,;24.16,-23.08,;23.39,-21.75,;25.7,-23.08,;26.47,-21.75,;28.01,-21.74,;25.69,-20.41,;27.22,-20.4,;23.39,-27.09,;24.17,-28.42,;24.93,-32.41,;24.16,-31.08,;24.16,-33.75,;29.55,-33.95,;30.32,-35.28,;30.07,-32.89,)|
Structure:
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