Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM50393671
Substrate
n/a
Meas. Tech.
ChEMBL_856311 (CHEMBL2160518)
IC50
>1000000±n/a nM
Citation
 Kapanda, CN; Masquelier, J; Labar, G; Muccioli, GG; Poupaert, JH; Lambert, DM Synthesis and pharmacological evaluation of 2,4-dinitroaryldithiocarbamate derivatives as novel monoacylglycerol lipase inhibitors. J Med Chem 55:5774-83 (2012) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM50393671
Synonyms:
CHEMBL2158905
Type:
Small organic molecule
Emp. Form.:
C25H24N2OS
Mol. Mass.:
400.536
SMILES:
O=C(C(=S)N1CCN(CC1)C(c1ccccc1)c1ccccc1)c1ccccc1
Structure:
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