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Target
Urea transporter 1
Ligand
BDBM50322183
Substrate
n/a
Meas. Tech.
ChEMBL_858438 (CHEMBL2168840)
IC50
212±n/a nM
Citation
 Anderson, MO; Zhang, J; Liu, Y; Yao, C; Phuan, PW; Verkman, AS Nanomolar potency and metabolically stable inhibitors of kidney urea transporter UT-B. J Med Chem 55:5942-50 (2012) [PubMed]  Article 
Target
Name:
Urea transporter 1
Synonyms:
Slc14a1 | Solute carrier family 14 member 1 | UT-B | UT1_MOUSE | Urea transporter B | Urea transporter, erythrocyte
Type:
PROTEIN
Mol. Mass.:
42130.98
Organism:
Mus musculus
Description:
ChEMBL_964780
Residue:
384
Sequence:
MEDSPTMVKVDRGENQILSCRGRRCGFKVLGYVTGDMKEFANWLKDKPVVLQFMDWILRGISQVVFVSNPISGILILVGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYNATLVGILMAVFSNKGDYFWWLIFPVSAMSMTCPVFSSALSSVLSKWDLPVFTLPFNMALSMYLSATGHYNTFFPSKLFTPVSSVPNITWSELSALELLKSLPVGVGQIYGCDNPWTGGIFLCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFEDIYFGLWGFNSSLACIAIGGMFMALTWQTHLLALACALFTAYFGACMAHLMAVVHLPACTWSFCLATLLFLLLTTKNPNIYRMPLSKVTYSEENRIFYLQNKKRMVESPL
  
Inhibitor
Name:
BDBM50322183
Synonyms:
3-(4-ethylphenylsulfonyl)-N-(3-methoxypropyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine | CHEMBL1173569 | UT-A1 inhibitor D4
Type:
Small organic molecule
Emp. Form.:
C19H21N5O3S2
Mol. Mass.:
431.532
SMILES:
CCc1ccc(cc1)S(=O)(=O)c1nnn2c3ccsc3c(NCCCOC)nc12
Structure:
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