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Target
Serine protease SplB
Ligand
BDBM50395595
Substrate
n/a
Meas. Tech.
ChEMBL_859707 (CHEMBL2169142)
Ki
4200±n/a nM
Citation
 Ewa, B; Maciej, W; Marcin, S; Grzegorz, D; Michal, Z; Jan, P; Józef, O The development of first Staphylococcus aureus SplB protease inhibitors: phosphonic analogues of glutamine. Bioorg Med Chem Lett 22:5574-8 (2012) [PubMed]  Article 
Target
Name:
Serine protease SplB
Synonyms:
SPLB_STAAU | splB
Type:
PROTEIN
Mol. Mass.:
26147.73
Organism:
Staphylococcus aureus
Description:
ChEMBL_859707
Residue:
240
Sequence:
MNKNVVIKSLATLTILTSVTGIGTTLVEEVQQTAKAENNVTKIQDTNIFPYTGVVAFKSATGFVVGKNTILTNKHVSKNYKVGDRITAHPNSDKGNGGIYSIKKIINYPGKEDVSVIQVEERAIERGPKGFNFNDNVTPFKYAAGAKAGERIKVIGYPHPYKNKYVLYESTGPVMSVEGSSIVYSAHTESGNSGSPVLNSNNELVGIHFASDVKNDDNRNAYGVYFTPEIKKFIAENIDK
  
Inhibitor
Name:
BDBM50395595
Synonyms:
CHEMBL2165309
Type:
Small organic molecule
Emp. Form.:
C35H44N5O9P
Mol. Mass.:
709.7257
SMILES:
CC(C)CC(NC(=O)C(CCC(N)=O)NC(=O)OCc1ccccc1)C(=O)NC(CCC(N)=O)P(=O)(Oc1ccccc1)Oc1ccccc1
Structure:
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