Reaction Details Report a problem with these data
Target
Cell division protein FtsZ
Ligand
BDBM50399003
Substrate
n/a
Meas. Tech.
ChEMBL_875260 (CHEMBL2187142)
Kd
3800±n/a nM
Citation
 Kaul, M; Parhi, AK; Zhang, Y; LaVoie, EJ; Tuske, S; Arnold, E; Kerrigan, JE; Pilch, DS A bactericidal guanidinomethyl biaryl that alters the dynamics of bacterial FtsZ polymerization. J Med Chem 55:10160-76 (2012) [PubMed]  Article 
Target
Name:
Cell division protein FtsZ
Synonyms:
FTSZ_ECOLI | ftsZ | sfiB | sulB
Type:
Protein
Mol. Mass.:
40305.83
Organism:
Escherichia coli
Description:
P0A9A6
Residue:
383
Sequence:
MFEPMELTNDAVIKVIGVGGGGGNAVEHMVRERIEGVEFFAVNTDAQALRKTAVGQTIQIGSGITKGLGAGANPEVGRNAADEDRDALRAALEGADMVFIAAGMGGGTGTGAAPVVAEVAKDLGILTVAVVTKPFNFEGKKRMAFAEQGITELSKHVDSLITIPNDKLLKVLGRGISLLDAFGAANDVLKGAVQGIAELITRPGLMNVDFADVRTVMSEMGYAMMGSGVASGEDRAEEAAEMAISSPLLEDIDLSGARGVLVNITAGFDLRLDEFETVGNTIRAFASDNATVVIGTSLDPDMNDELRVTVVATGIGMDKRPEITLVTNKQVQQPVMDRYQQHGMAPLTQEQKPVAKVVNDNAPQTAKEPDYLDIPAFLRKQAD
  
Inhibitor
Name:
BDBM50399003
Synonyms:
CHEMBL2180486
Type:
Small organic molecule
Emp. Form.:
C18H23N3
Mol. Mass.:
281.3953
SMILES:
[#6]C([#6])([#6])c1ccc(cc1)-c1cccc(-[#6]\[#7]=[#6](\[#7])-[#7])c1
Structure:
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