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Target
dTMP kinase
Ligand
BDBM50400452
Substrate
n/a
Meas. Tech.
ChEMBL_877484 (CHEMBL2183638)
Ki
15000±n/a nM
Citation
 Cui, H; Carrero-Lérida, J; Silva, AP; Whittingham, JL; Brannigan, JA; Ruiz-Pérez, LM; Read, KD; Wilson, KS; González-Pacanowska, D; Gilbert, IH Synthesis and evaluation ofa-thymidine analogues as novel antimalarials. J Med Chem 55:10948-57 (2012) [PubMed]  Article 
Target
Name:
dTMP kinase
Synonyms:
TMK | Thymidylate kinase, putative
Type:
PROTEIN
Mol. Mass.:
24691.81
Organism:
Plasmodium falciparum (isolate 3D7)
Description:
ChEMBL_877484
Residue:
210
Sequence:
MTDDKKKGKFIVFEGLDRSGKSTQSKLLVEYLKNNNVEVKHLYFPNRETGIGQIISKYLKMENSMSNETIHLLFSANRWEHMNEIKSLLLKGIWVVCDRYAYSGVAYSSGALNLNKTWCMNPDQGLIKPDVVFYLNVPPNYAQNRSDYGEEIYEKVETQKKIYETYKHFAHEDYWINIDATRKIEDIHNDIVKEVTKIKVEPEEFNFLWS
  
Inhibitor
Name:
BDBM50400452
Synonyms:
CHEMBL2179041
Type:
Small organic molecule
Emp. Form.:
C17H19BrN4O5
Mol. Mass.:
439.261
SMILES:
Cc1cn([C@H]2C[C@H](O)[C@@H](CNC(=O)Nc3ccc(Br)cc3)O2)c(=O)[nH]c1=O |r|
Structure:
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