Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50400742
Substrate
n/a
Meas. Tech.
ChEMBL_880513 (CHEMBL2211448)
Ki
4.2±n/a nM
Citation
 Yu, LF; Zhang, HK; Gunosewoyo, H; Kozikowski, AP From a4ß2 Nicotinic Ligands to the Discovery of s1 Receptor Ligands: Pharmacophore Analysis and Rational Design. ACS Med Chem Lett 3:1054-1058 (2012) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50400742
Synonyms:
CHEMBL2165453
Type:
Small organic molecule
Emp. Form.:
C15H18N2O3
Mol. Mass.:
274.315
SMILES:
C(Oc1cc(COc2ccccc2)no1)[C@@H]1CCCN1 |r|
Structure:
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