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Target
C-C chemokine receptor type 8
Ligand
BDBM50401354
Substrate
n/a
Meas. Tech.
ChEMBL_884037 (CHEMBL2215086)
EC50
398.11±n/a nM
Citation
 Thiele, S; Malmgaard-Clausen, M; Engel-Andreasen, J; Steen, A; Rummel, PC; Nielsen, MC; Gloriam, DE; Frimurer, TM; Ulven, T; Rosenkilde, MM Modulation in selectivity and allosteric properties of small-molecule ligands for CC-chemokine receptors. J Med Chem 55:8164-77 (2012) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 8
Synonyms:
CCR8 | CCR8_HUMAN | CKRL1 | CMKBR8 | CMKBRL2
Type:
PROTEIN
Mol. Mass.:
40855.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_454278
Residue:
355
Sequence:
MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL
  
Inhibitor
Name:
BDBM50401354
Synonyms:
CHEMBL2205805
Type:
Small organic molecule
Emp. Form.:
C15H10ClN3
Mol. Mass.:
267.713
SMILES:
Clc1cc(nc(c1)-c1ccccn1)-c1ccccn1
Structure:
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