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Target
Guanine deaminase
Ligand
BDBM50401837
Substrate
n/a
Meas. Tech.
ChEMBL_885179 (CHEMBL2213713)
IC50
5000±n/a nM
Citation
 Chakraborty, S; Shah, NH; Fishbein, JC; Hosmane, RS Investigations into specificity of azepinomycin for inhibition of guanase: discrimination between the natural heterocyclic inhibitor and its synthetic nucleoside analogues. Bioorg Med Chem Lett 22:7214-8 (2012) [PubMed]  Article 
Target
Name:
Guanine deaminase
Synonyms:
GAH | GDA | GUAD_HUMAN | Guanase | Guanine aminase | Guanine aminohydrolase | KIAA1258 | p51-nedasin
Type:
PROTEIN
Mol. Mass.:
50993.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_885179
Residue:
454
Sequence:
MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV
  
Inhibitor
Name:
BDBM50401837
Synonyms:
CHEMBL2203870
Type:
Small organic molecule
Emp. Form.:
C6H8N4O2
Mol. Mass.:
168.1533
SMILES:
OC1CNc2nc[nH]c2C(=O)N1
Structure:
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