Reaction Details Report a problem with these data
Target
Hexokinase-4
Ligand
BDBM50401855
Substrate
n/a
Meas. Tech.
ChEMBL_885387 (CHEMBL2216128)
EC50
1930±n/a nM
Citation
 Pfefferkorn, JA; Tu, M; Filipski, KJ; Guzman-Perez, A; Bian, J; Aspnes, GE; Sammons, MF; Song, W; Li, JC; Jones, CS; Patel, L; Rasmusson, T; Zeng, D; Karki, K; Hamilton, M; Hank, R; Atkinson, K; Litchfield, J; Aiello, R; Baker, L; Barucci, N; Bourassa, P; Bourbounais, F; D'Aquila, T; Derksen, DR; MacDougall, M; Robertson, A The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of type 2 diabetes mellitus. Bioorg Med Chem Lett 22:7100-5 (2012) [PubMed]  Article 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50401855
Synonyms:
CHEMBL2204649
Type:
Small organic molecule
Emp. Form.:
C21H19N5O4S
Mol. Mass.:
437.472
SMILES:
Cc1cnc(NC(=O)c2cc(Oc3ccc(cc3)S(C)(=O)=O)c3cn(C)nc3c2)cn1
Structure:
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